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hcar2 gi complexes  (TargetMol)


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    Structured Review

    TargetMol hcar2 gi complexes
    Figure 7. Mechanism <t>of</t> <t>HCAR2-Gi</t> coupling (A) Structural comparison of the GSK256073- bound HCAR2-Gi complex with representative class A Gi-coupled D2R (PDB: 7JVR). (B and C) Detailed interactions between Gai and HCAR2. The polar interactions are depicted by black dashed lines. See also Figure S9.
    Hcar2 Gi Complexes, supplied by TargetMol, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hcar2+gi+complexes/Anti-GPR109A+Polyclonal+Antibody/pm37952153-209-1-13
    Average 91 stars, based on 1 article reviews
    hcar2 gi complexes - by Bioz Stars, 2026-09
    91/100 stars

    Images

    1) Product Images from "Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2."

    Article Title: Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2.

    Journal: Cell reports

    doi: 10.1016/j.celrep.2023.113406

    Figure 7. Mechanism of HCAR2-Gi coupling (A) Structural comparison of the GSK256073- bound HCAR2-Gi complex with representative class A Gi-coupled D2R (PDB: 7JVR). (B and C) Detailed interactions between Gai and HCAR2. The polar interactions are depicted by black dashed lines. See also Figure S9.
    Figure Legend Snippet: Figure 7. Mechanism of HCAR2-Gi coupling (A) Structural comparison of the GSK256073- bound HCAR2-Gi complex with representative class A Gi-coupled D2R (PDB: 7JVR). (B and C) Detailed interactions between Gai and HCAR2. The polar interactions are depicted by black dashed lines. See also Figure S9.

    Techniques Used: Comparison

    Related Articles

    Comparison:

    Article Title: Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2.
    Article Snippet: Cell pellets were thawed and lysed in 20 mM HEPES, PH 7.4,100 mM NaCl, 10% glycecerol, 5 mM CaCl2, 5 mM MgCl2, supplemented with 25 mU ml 1 apyrase and Protease Inhibitor Cocktail, EDTA-Free (TargetMol).Cell pellets were thawed and lysed in 20 mM HEPES, PH 7.4,100 mM NaCl, 10% glycecerol, 5 mM CaCl2, 5 mM MgCl2, supplemented with 25 mU ml 1 apyrase and Protease Inhibitor Cocktail, EDTA-Free (TargetMol).. The HCAR2-Gi complexes were formed in membranes by the addition of 40mM Niacin (TargetMol), or 20mM MK-6892 (TargetMol), or 40mM GSK256073 (TargetMol), respectively.. The suspension was incubated for 1.5 h at room temperature.The suspension was incubated for 1.5 h at room temperature.



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    Figure 7. Mechanism <t>of</t> <t>HCAR2-Gi</t> coupling (A) Structural comparison of the GSK256073- bound HCAR2-Gi complex with representative class A Gi-coupled D2R (PDB: 7JVR). (B and C) Detailed interactions between Gai and HCAR2. The polar interactions are depicted by black dashed lines. See also Figure S9.
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    Figure 7. Mechanism <t>of</t> <t>HCAR2-Gi</t> coupling (A) Structural comparison of the GSK256073- bound HCAR2-Gi complex with representative class A Gi-coupled D2R (PDB: 7JVR). (B and C) Detailed interactions between Gai and HCAR2. The polar interactions are depicted by black dashed lines. See also Figure S9.
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    Image Search Results


    Figure 7. Mechanism of HCAR2-Gi coupling (A) Structural comparison of the GSK256073- bound HCAR2-Gi complex with representative class A Gi-coupled D2R (PDB: 7JVR). (B and C) Detailed interactions between Gai and HCAR2. The polar interactions are depicted by black dashed lines. See also Figure S9.

    Journal: Cell reports

    Article Title: Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2.

    doi: 10.1016/j.celrep.2023.113406

    Figure Lengend Snippet: Figure 7. Mechanism of HCAR2-Gi coupling (A) Structural comparison of the GSK256073- bound HCAR2-Gi complex with representative class A Gi-coupled D2R (PDB: 7JVR). (B and C) Detailed interactions between Gai and HCAR2. The polar interactions are depicted by black dashed lines. See also Figure S9.

    Article Snippet: The HCAR2-Gi complexes were formed in membranes by the addition of 40mM Niacin (TargetMol), or 20mM MK-6892 (TargetMol), or 40mM GSK256073 (TargetMol), respectively.

    Techniques: Comparison